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Responsibilities
Onsite
Schedule: 9a-5p (flexibility in the scheduling for 8a-4p).
This role is lab-based with an equal amount of office work (Lab book entries, Group meetings, Group presentations). Requires Cell Culture experience in the lab. The position is collaborative, looking for a candidate with 4+ years of experience developing complex assays. The office culture consists of smaller groups and is more intellectually stimulating than typical industry roles.
Scientist (non-PhD) – ADC Biology
ROLE SUMMARY
As a Scientist (non-PhD) on our ADC Biology team, you will be a key driver in advancing next-generation ADC technologies through collaborative, cross-functional research that spans from early discovery to pre-clinical development. You will develop assays and execute screening and identification of novel chemotypes that function as payloads for antibody-drug conjugates (ADCs) for cancer therapy. You will work collaboratively with chemistry and other cross-functional teams to understand the mechanisms of action of identified payloads. You will analyze, interpret, and communicate the data effectively to key stakeholders.
KEY RESPONSIBILITIES
* Apply cellular, biochemical, immunological, and molecular biology laboratory techniques to preclinical research projects in Cancer signaling and Cancer biology.
* Investigate mechanisms of action (MOAs) of therapeutics through the development, optimization, and execution of complex assays.
* Interact and collaborate with other functional groups across research.
* Provide leadership within technical areas of expertise; may train, direct, or mentor others.
* Design and execute key experiments to investigate novel therapeutic targets and MOAs of novel payloads to enable clear go/no-go decisions.
* Independently analyze data, document results, and present findings to large and small audiences.
* Maintain rigorous records of experimental progress using electronic laboratory notebooks.
* Present experimental results and scientific rationale to colleagues.
* Execute molecular, biochemical, and cell-based methodologies, including cytotoxicity assays, HiBit, HTRF, ELISA, western blotting, automated liquid handling, multicolor flow cytometry, immunofluorescence, and live cell microscopy.
* Aid in the execution and analysis of additional experiments as needed within the ADC discovery research team.
MINIMUM REQUIREMENTS
* Bachelor’s degree in Cellular or Molecular Biology, Immunology, Biochemistry, or related field with 6+ years of relevant industry experience, OR
* M.S. degree in Cellular or Molecular Biology, Immunology, Biochemistry, or related field with 4+ years of relevant industry experience.
* Experience with Microsoft Office (Excel, Word, PowerPoint) and analytical software programs (e.g., Prism, FlowJo).
* Experience designing, performing, and interpreting complex experiments that require significant insight into problems, with some guidance.
* Working knowledge in Cancer Biology and Cancer therapeutics, especially small molecule agents, biologics, and ADCs.
* Experience working independently and managing multiple projects.
* Experience collaborating across teams and a variety of disciplines to provide experimental expertise and support others on joint projects.
* Experience leading parts of projects or initiatives within your area of expertise.
* Excellent written and oral communication skills, with experience presenting work to key stakeholders.
PREFERRED REQUIREMENTS
* Experience in experimental cancer biology, biochemical and/or immunological techniques (e.g., cell culture, cytotoxicity assays, HiBit, HTRF, ELISA, western blotting, automated liquid handling, multicolor flow cytometry, immunofluorescent and live cell microscopy).
* Background knowledge in cell signaling and biochemistry.
* Experience developing complex cell and biochemical assays.
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