ABOUT FORESIGHT DIAGNOSTICSForesight Diagnostics is a molecular diagnostics company pioneering non-invasive cancer detection through highly sensitive, cell-free DNA-based liquid biopsy technologies. Our proprietary methods - originally developed at Stanford University - are designed to detect smaller tumors earlier and enable more personalized treatment strategies for patients with cancer.We sit at the intersection of molecular biology, bioinformatics, and next-generation sequencing (NGS), and we translate rigorous science into clinically meaningful solutions. Following our acquisition by Natera, we now combine the agility of a mission-driven startup with the scale and resources of a global leader in cell-free DNA testing. It’s an exciting moment to join us.Headquartered in Boulder, Colorado, our team operates in a high accountability, collaborative environment where quality and continuous improvement aren’t just values - they’re how we work every day.WHY THIS ROLE EXISTSThe Senior Program Manager will lead complex, cross-functional initiatives supporting operational programs at both the Austin, TX and Boulder, CO sites. Projects and Programs may include operational and site readiness for product and clinical trial launches; initiatives to improve, scale, or automate wet lab and dry lab workflows; and product sustainment and lifecycle management efforts, such as change management for reagent obsolescence, supplier transitions, and integration of vendor-driven software or platform upgrades.This role owns end-to-end program strategy and execution, aligning stakeholders across laboratory operations, clinical development, R&D, manufacturing, regulatory, quality, software, and external partners. The Senior Program Manager will own, drive, communicate, and engage all project partners to enable accountability, problem solving, and on-time/within-budget delivery for simultaneous projects and programs. Success in this role requires onsite engagement (up to 25% travel) to facilitate rapid decision-making, build alignment, and resolve issues in a highly collaborative, fast-paced setting. This position reports to the Associate Director of Program Management.WHAT YOU’LL DOOwn end-to-end delivery of complex operational programs, including scope, schedule, budget, and resource strategy, ensuring alignment with regulatory and business requirementsLead cross-functional program execution across laboratory operations, clinical operations, R&D, and external partners to deliver on translational research, clinical, and commercial timelinesDrive operational readiness initiatives, including laboratory site readiness for product and clinical trial launches, and process implementation across wet lab and dry lab workflowsAdhere to and facilitate the formal governance processes to communicate program status, risks, dependencies, and trade-offs; escalate issues as needed; and present data-driven recommendations and business proposals to senior leadership to enable timely, informed decision-makingDevelop and maintain program roadmaps, ensuring alignment with organizational priorities and securing stakeholder buy-inExtract and refine user needs and requirements from stakeholders and lead teams to focus on the most valuable deliverablesLead risk and issue management, proactively identifying, mitigating, and resolving complex technical and operational challengesEnsure adherence to regulated processes, including design controls, change management, and quality system requirements (FDA, CAP/CLIA)Drive cross-functional accountability, influencing without direct authority to ensure alignment, ownership, and timely executionPartner with Alliance Management and external stakeholders to ensure seamless execution of joint programs and delivery commitmentsChampion continuous improvement throughout the organization, identifying and acting on opportunities to enhance operational efficiencyCultivate, build and maintain positive and collaborative relationships with cross-functional teamsWHAT YOU’LL BRING5-7+ years of experience in program management, or equivalent combination of project and program management and relevant functional experience in biotechnology, diagnostics, clinical laboratory, or life sciencesExperience supporting laboratory operations, clinical operations and trial execution (preferred)Background in NGS diagnostics, including assay and software components (MRD experience preferred)Strong familiarity with FDA, CAP/CLIA, and design control processesPMP or equivalent certification (strongly preferred)Proven ability to influence senior stakeholders and drive alignment in matrixed organizationsDemonstrated success leading complex, cross-functional programs from concept through commercializationStrong analytical and operational mindset, with the ability to translate complex data into actionable insightsExcellent executive communication skills, with the ability to tailor messaging across technical and non-technical audiencesExperience building and scaling program management tools, frameworks, and governance modelsProficiency with program management and collaboration tools (e.g., Smartsheet, Jira, Office Timeline, etc.)Ability to manage multiple concurrent programs in a fast-paced, high-growth environmentSituational awareness, coupled with facilitation, problem solving, and conflict resolution skills to drive cross-functional decision-makingThis position may be required to work across time zones as needed to support project schedulesCOMPENSATION, BENEFITS & EQUAL OPPORTUNITYThis role offers a competitive annual base compensation of $145,000 - $165,000 commensurate with experience, and a comprehensive benefits package including:Medical, dental, and visionFlexible PTO and paid holidaysParental leave401(k) with company matchWe promote the professional development of our teams and encourage upward mobility within the company for high performing employees. Foresight Diagnostics is an equal opportunity employer.
