Jonathan Sage
About
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Vice President of Engineering
Redmond, Washington, United States
Résumé
Jobs
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Vice President of EngineeringAledade IncApr 2026 - Current (5 months)- Senior Director of EngineeringAledade IncApr 2024 - Mar 2026 (2 years)
- Director of EngineeringAledade IncApr 2020 - Mar 2024 (4 years)Volunteered as hiring captain and helped implement many changes to our long-standing hiring procedure. Gained my first engineering manager report. Through doggedly participating in hiring, I have scaled our engineering team. As a manager at Aledade, I hired 28 of our total 61 software engineers. Worked to continue adoption of the Objectives and Key Results (OKR) framework. Spearheaded a migration of our reporting database to Snowflake from Postgres. This migration eliminated the need for logical replication, saving ~2+ FTEs worth of toil managing the legacy system. Advocated for, and managed, a team that moved a high resource contention process off of our production database over to Snowflake, eliminating the need for weekend-only proce
- Engineering ManagerAledade IncMay 2019 - Mar 2020 (11 months)Oversaw technical design of our medication adherence platform that earned $22M in 2019. Led infrastructure roadmapping. Served as a key thought leader in selecting projects for development. Transitioned my team to run on the Objectives and Key Results (OKR) framework.
- Technical Lead Software EngineerAledade IncJan 2018 - Apr 2019 (1 year 4 months)Provided thoughtful code review and mentorship to newer engineers. Switched our build process from buildout to pip, reducing build times by 2 orders of magnitude. Became a database replication expert and helped set best practices for the team. Gained my first direct report in March of 2018 with the intent to build up a team. Stepped up and formally took on management of the architecture engineering team, when, over the course of a single month starting May 2018, our VP of engineering was let go and all three directors of engineering resigned. Despite those departures, I stabilized the team and retained 100% of my direct reports.
- Software EngineerAledade IncOct 2016 - Dec 2017 (1 year 3 months)Independently maintained myriad core systems. Reliably delivered sprint work on time and picked up extra work each sprint. Consistently surfaced potential system improvements. Designed and implemented a commercial insurance payer data ingestion system which supported $5M in 2017 revenue. Improved performance of the patient matching algorithm by ~50x.
- SBioinformatics SpecialistStirplateioMar 2015 - Sep 2016 (1 year 7 months)Ground level member of a small and talented team. Stirplate.io launched in mid 2015 as a cloud based next generation sequencing analysis platform. I developed a fully automated RNAseq pipeline using FastQC, Tophat/STAR, Samtools, and DEseq. This was programmed in python with statistical R programming integrated by rpy2. These services were built into Docker containers that could be spun up when work was ready to be consumed. The application relied upon RabbitMQ as a publisher/subscriber durable work messaging service. I became responsible for development and maintenance of the Stirplate API built with python and the falcon framework to use a Postgresql DB, Redis annotations data store, Redis query caching, and AWS S3 data storage. I also la
- Web DeveloperQuadsimia LLCJan 2015 - Mar 2015 (3 months)I did frontend (javascript with jquery) and backend (php) programming for contract work.
- Research Technician IIIMitoSciences an AbCam CompanyFeb 2011 - Aug 2012 (1 year 7 months)I worked in Research & Development through all steps of antibody development. This includes IP injection, splenocyte harvesting, fusion, hybridoma cell culture and selection, and antibody characterization. Antibody selection and characterization utilize techniques such as: ELISA, Western Blot, and MPIC. I also worked on antibody assay development. Several techniques are utilized during assay development including: pair test sandwich ELISA, immunocytochemistry, in-cell ELISA, and flow cytometry.
- Graduate Teaching FellowUniversity of OregonSep 2008 - Dec 2010 (2 years 4 months)
- Undergraduate ResearcherWestern Washington UniversitySep 2006 - Jun 2008 (1 year 10 months)
Education
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- Master's degree, BioinformaticsThe Johns Hopkins UniversityJan 2012 - Jan 2014 (2 years 1 month)Course Work Included: Introduction to Java Introduction to Python Datastructures in Java Foundations of Algorithms Web Application Development with Java Rich Internet Applications with Ajax Practical Computer Concepts for Bioinformatics Advanced Practical Computer Concepts for Bioinformatics Introduction to Bioinformatics Gene Organization & Expression Genomic and Personalized Medicine Epidemiology: Diseases in Populations Biostatistics Microarrays & Analysis Practical Introduction to Metagenomics
- Master's degree, ChemistryUniversity of OregonJan 2008 - Jan 2010 (2 years 1 month)
- Bachelor of Science, BiochemistryWestern Washington UniversityJan 2005 - Jan 2008 (3 years 1 month)
Publications
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- JMosaic analysis with double markers reveals tumor cell of origin in gliomaJulCancer cell of origin is difficult to identify by analyzing cells within terminal stage tumors, whose identity could be concealed by the acquired plasticity. Thus, an ideal approach to identify the cell of origin is to analyze proliferative abnormalities in distinct lineages prior to malignancy. Here, we use mosaic analysis with double markers (MADM) in mice to model gliomagenesis by initiating concurrent p53/Nf1 mutations sporadically in neural stem cells (NSCs). Surprisingly, MADM-based lineage tracing revealed significant aberrant growth prior to malignancy only in oligodendrocyte precursor cells (OPCs), but not in any other NSC-derived lineages or NSCs themselves. Upon tumor formation, phenotypic and transcriptome analyses of tumor cell